ERA4TB Granuloma-Like Structure (GLS) and Host-Pathogen Interaction (HPI) Assays

The granuloma-like structure (GLS) and host-pathogen interaction (HPI) assays are in vitro platforms that model how Mycobacterium tuberculosis behaves inside a human immune-cell environment, rather than in isolation. They allow the consortium to screen and prioritise candidate compounds and combinations for how well they act against bacteria in a setting that resembles a genuine TB lesion – including within macrophages and structures that mimic granulomas – before compounds progress to animal studies. 

 

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