About the AMR Accelerator
The AMR Accelerator programme was launched in 2019, with the aim to accelerate the development of medicines for patients suffering from infections with drug-resistant Mycobacterium tuberculosis, nontuberculous mycobacteria (NTM), and Gram-negative bacteria, and build capability for antibiotics research and development. The programme is funded by the Innovative Medicines Initiative (IMI). The AMR Accelerator programme includes nine projects: AB-Direct, COMBINE, ERA4TB, GNA NOW, PrIMAVeRa, RespiriNTM, RespiriTB, TRIC-TB, and UNITE4TB. Together, the projects have a €479 million budget. The 98 partners represent key stakeholders from academia, industry, small- and medium-sized companies, patient organisations, regulators, and Health Technology Assessment.
About COMBINE
COMBINE has a coordinating role in the AMR Accelerator, and a scientific mission aiming to improve 1) the design and analysis of clinical trials, and 2) animal infection model reproducibility and translation to clinical efficacy. COMBINE has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No 853967.
Anders Karlén, Professor of Computer-Aided Drug Design, Uppsala University and COMBINE Coordinator.
Email: anders.karlen@ilk.uu.se
Marie Olliver, COMBINE Alliance Manager, Uppsala University
Email: marie.olliver@ilk.uu.se
About ERA4TB
The ERA4TB (European Accelerator of Tuberculosis Regime) project is devoted to creating a European Open platform to accelerate the development of new treatment regimens for tuberculosis. ERA4TB is expected to revolutionize the way in which tuberculosis treatments are developed thanks to its parallelized, multi-entry pipeline structure. By the end of the project the consortium expects to have developed at least two or more new combination regimens with treatment-shortening potential ready for Phase II clinical evaluation.
This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 853989. The JU receives support from the European Union’s Horizon 2020 research and innovation programme, EFPIA, the Global Alliance for TB Drug Development non-profit organisation, the Bill & Melinda Gates Foundation, and the University of Dundee.
Juan Jose Vaquero, Professor of Bioengineering and ERA4TB Technical Coordinator, Universidad Carlos III de Madrid.
Email: juanjose.vaquero@uc3m.es
Katharine Cresswell, ERA4TB communications and engagement, National Institute for Health and Care Excellence.
Email: Katharine.cresswell@nice.org.uk
About GNA NOW
Established in 2019, the GNA NOW Consortium (Gram-Negative Antibacterials NOW), is a joint initiative of 11 partners from industry and academia, aimed at delivering Gram-negative antibacterials with new modes of action to the clinical phase. The Consortium is focused on progressing treatments for severe diarrhoea, targeting four enteric pathogens: Shigella, Campylobacter, E. coli, and Salmonella. The Consortium consists of GSK (Scientific Lead), BioAster, Erasmus MC, Fraunhofer, Helmholtz Centre for Infection Research, Inserm, Medical University of Vienna, North Bristol NHS Trust, University of Liverpool, University of Poitiers, and Lygature (Coordinator).
Find out more: www.amr-accelerator.eu/project/gna-now/
About the Innovative Medicine Initiative
About the Innovative Medicine Initiative The Innovative Medicines Initiative (IMI) is Europe’s largest public-private initiative aiming to speed up the development of better and safer medicines for patients. IMI supports collaborative research projects and builds networks of industrial and academic experts in order to boost pharmaceutical innovation in Europe. IMI is a joint undertaking between the European Union and the European Federation of Pharmaceutical Industries and Associations, EFPIA.
For more information on IMI, please visit https://www.imi.europa.eu/
Disclaimer
This communication reflects the views of the authors and neither IMI nor the European Union and EFPIA are liable for any use that may be made of the information contained herein.
