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EXPERT WORKSHOP: Advancing towards a standardized murine model to evaluate treatments for AMR lung infections

27. April 2021 @ 3:00 PM - 28. April 2021 @ 7:00 PM CEST

The COMBINE project is part of the IMI AMR Accelerator. One of the scientific aims of COMBINE is to improve and standardize the pneumonia animal model used in AMR research and to develop improved tools to reliably translate results in animals into results in humans.

Aim of the workshop: This workshop will address the need for standard protocols to ease harmonization of non-clinical efficacy data and facilitate the establishment of standardized high-quality infection models. We will focus on preclinical lung infection models for the most relevant Gram-negative AMR pathogens (K. pneumoniae, P. aeruginosa and A. baumannii). Our speakers and panelists will discuss previously identified factors of variability in murine pneumonia infection model protocols. Moreover, this webinar will provide an open discussion forum aimed at reaching a consensus to establish a standardized high-quality preclinical murine pneumonia model for PK/PD analysis of small-molecule antibiotics. Further, we will explore protocol adjustments for efficacy studies beyond PK/PD.

Speakers & Panelists: Experts on murine lung infection models from academia, industry and regulatory agencies will present and discuss parameters for PK/PD of small-molecule antibiotics and special considerations for additional readouts or alternative applications of these models.

Participation: This free online workshop will be of particular interest to investigators applying preclinical murine models for efficacy and PK/PD assessment.

Day 1, Tuesday April 27th 2021 (15:00-19:00 CEST)

Developing a standardized murine pneumonia model to characterize PK/PD of antibiotics

Day 2, Wednesday, April 28th 2021 (15:00-19:00 CEST)

Standard protocols for murine pneumonia models – beyond PK/PD

15:00 – 15:20 Welcome and introduction

15:20 – 15:45 Parameters that are important for murine pneumonia model used for PK/PD characterization and recommendations for a standard protocol

15:45 – 16:10 Impact of murine pneumonia infection model and treatment regimen in antibiotics efficacy

Biobreak

16:25 – 18:45 Panel Discussion: murine pneumonia model variables to standardize PK/PD analysis of small-molecule antibiotics

18:45 – 19:00 Wrap-up & Survey

15:00 – 15:10 Welcome/Introduction

15:10 – 15:40 Murine pneumonia model special considerations for bacteriophages efficacy testing

15:40 – 16:10 Murine pneumonia model special considerations for monoclonal antibodies efficacy testing

16:10 – 16:30 Murine pneumonia model special considerations for Iron sequestering anti-infectives efficacy testing

Biobreak

16:55 – 17:25 Importance of Epithelial Lining Fluid (ILF) in PK/PD characterization for pneumonia and procedures for collecting and analyzing ELF from mice

17:25 – 17:55 Murine pneumonia model special considerations for ß-lactam/ß-lactamase inhibitor (BL/BLI) testing

17:55 – 18:25 Murine pneumonia model special considerations for A. baumannii infection

18:25 – 18:50 Survey results presentation

18:50 – 19:00 Wrap-up

The workshop will be recorded for the sole purpose of creating an accurate meeting report.

 

 

>>> DOWNLOAD THE EVENT FLYER HERE <<<

Please note that individual registration for both days is required.

For additional information, or assistance with the registration, please contact imi-combine@pei.de.


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Details

Start:
27. April 2021 @ 3:00 PM CEST
End:
28. April 2021 @ 7:00 PM CEST
Event Categories:
,

Venue

Online
RI

Organizer

COMBINE
Email:
amr-accelerator@biocom.de
Website:
https://amr-accelerator.eu/project/combine/

Details

Start:
27. April 2021 @ 3:00 PM CEST
End:
28. April 2021 @ 7:00 PM CEST
Event Categories:
,

Venue

Online
RI

Organizer

COMBINE
Email:
amr-accelerator@biocom.de
Website:
https://amr-accelerator.eu/project/combine/