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EXPERT WORKSHOP: Advancing towards a standardized murine model to evaluate treatments for AMR lung infections

27. April 2021 @ 3:00 PM - 28. April 2021 @ 7:00 PM

The COMBINE project is part of the IMI AMR Accelerator. One of the scientific aims of COMBINE is to improve and standardize the pneumonia animal model used in AMR research and to develop improved tools to reliably translate results in animals into results in humans.

Aim of the workshop: This workshop will address the need for standard protocols to ease harmonization of non-clinical efficacy data and facilitate the establishment of standardized high-quality infection models. We will focus on preclinical lung infection models for the most relevant Gram-negative AMR pathogens (K. pneumoniae, P. aeruginosa and A. baumannii). Our speakers and panelists will discuss previously identified factors of variability in murine pneumonia infection model protocols. Moreover, this webinar will provide an open discussion forum aimed at reaching a consensus to establish a standardized high-quality preclinical murine pneumonia model for PK/PD analysis of small-molecule antibiotics. Further, we will explore protocol adjustments for efficacy studies beyond PK/PD.

Speakers & Panelists: Experts on murine lung infection models from academia, industry and regulatory agencies will present and discuss parameters for PK/PD of small-molecule antibiotics and special considerations for additional readouts or alternative applications of these models.

Participation: This free online workshop will be of particular interest to investigators applying preclinical murine models for efficacy and PK/PD assessment.

Day 1, Tuesday April 27th 2021 (15:00-19:00 CEST)

Developing a standardized murine pneumonia model to characterize PK/PD of antibiotics

Day 2, Wednesday, April 28th 2021 (15:00-19:00 CEST)

Standard protocols for murine pneumonia models – beyond PK/PD

15:00 – 15:20 Welcome and introduction to the workshop goals

15:20 – 16:30 Presentations focusing on protocol parameters and variables, sampling and translation

16:45 – 18:45 Panel Discussion

18:45 – 19:00 Wrap up & Survey

15:00 – 15:10 Welcome

15:10 – 15:40 Survey results & Discussion

15:40 –18:30 Presentations exploring further readouts, drug products and specific pathogens

18:30-19:00 Wrap up

The workshop will be recorded for the sole purpose of creating an accurate meeting report.

 

 

>>> DOWNLOAD THE EVENT FLYER HERE <<<

Please note that individual registration for both days is required.

For additional information, or assistance with the registration, please contact imi-combine@pei.de.


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Details

Start:
27. April 2021 @ 3:00 PM
End:
28. April 2021 @ 7:00 PM
Event Category:

Venue

Online

Organizer

COMBINE
Email:
amr-accelerator@biocom.de
Website:
https://amr-accelerator.eu/project/combine/

Details

Start:
27. April 2021 @ 3:00 PM
End:
28. April 2021 @ 7:00 PM
Event Category:

Venue

Online

Organizer

COMBINE
Email:
amr-accelerator@biocom.de
Website:
https://amr-accelerator.eu/project/combine/