About twenty people attended this webinar which focused on some highlights and challenges from three TB focused projects, namely UNITE4TB, ERA4TB, and TRIC-TB. The selected speakers, Modesto Remuinan-Blanco (TRIC-TB and GSK), Martin Boeree (UNITE4TB and Radboud UMC), Alfonso Mendoza-Losana (ERA4TB and Universidad Carlos III Madrid) and Oscar della Pasqua (ERA4TB and Consiglia Nazionale delle Ricerche) shared some of the challenges they have been facing within their projects and how they are addressing these. In the last part of this webinar, Frederik Deroose (Connecting Pharma) hosted a panel with whom he discussed and addressed the scientific challenges of the TB research as a global area of interest.