This webinar provided an overview of animal infection models commonly used for studies of antibiotics against gram-negative bacteria. The webinar was driven by the COMBINE objective to harmonse and standardise a protocol for a mouse infection model used for efficacy and PKPD studies. The infection model was validated through well-characterised bacterial strains and control compounds in different animal labs. During the webinar we initiated a discussion on pro’s and con’s of various procedures and animal models, aiming to guide which animal infection model COMBINE should focus on.
Sylvie Sordello, COMBINE WP5 and Evotec
Jon Hansen, COMBINE WP5 and Statens Serum Institut
Jennifer Hoover, COMBINE WP5 and GlaxoSmithKline